COMPOSITION Dexkof Plus Syrup: Each 5 ml Syrup contains Dextromethorphan Hydrobromide BP 20 mg, Phenylephrine Hydrochloride BP 10 mg and Triprolidine Hydrochloride BP 2.5 mg. PHARMACOLOGY Dexkof Plus Syrup is a mixture of antitussive, decongestant and antihistamine agent. Dextromethorphan is used to suppress dry cough. Dextromethorphan is safe, effective and non-narcotic antitussive. It blocks the cough reflex in situations where the dry cough serves no purpose. It does so by calming the cough centre of the brain that governs the coughing reflex. Dextromethorphan does not induce tolerance, and has no potential for addiction like opiates. Phenylephrine is a sympathomimetic amine that acts predominantly on -adrenergic receptors. It is mainly used to treat nasal congestion. Triprolidine is a strong antihistamine, which acts on histamine (H1) receptors. Antihistamines block the action of histamine, preventing dilatation of blood vessels, reducing redness and swelling. It may cause mild drowsiness INDICATIONS Dexkof Plus Syrup, the combination of Triprolidine, Phenylephrine and Dextromethorphan is used to relieve the symptoms of colds and flu, runny nose, nasal congestion and cough, where these are associated with dry cough.