COMPOSITION Cefone 250 mg IM Injection: Each vial contains 250 mg of Ceftriaxone as sterile Ceftriaxone Sodium USP. Cefone 500 mg IM Injection: Each vial contains 500 mg of Ceftriaxone as sterile Ceftriaxone Sodium USP. Cefone 1 g IV Injection: Each vial contains 1 g of Ceftriaxone as sterile Ceftriaxone Sodium USP. Cefone 2 g IV Injection: Each vial contains 2 g of Ceftriaxone as sterile Ceftriaxone Sodium USP. Lidocaine Solution: Each ampoule contains 2 ml of Lidocaine Hydrochloride BP 1% Injection for reconstitution. Water for Injection: Each ampoule contains 10 ml sterile Water for Injection BP for reconstitution. PHARMACOLOGY Ceftriaxone (Cefone) is a third generation parenteral cephalosporin antibiotic which has potent bactericidal activity against a wide range of gram-positive and especially gram-negative organisms. Ceftriaxone (Cefone), like other cephalosporins and penicillins, kills bacteria by interfering bacterial cell wall synthesis. The spectrum of activity includes both aerobic and some anaerobic species. It has considerable stability against degradation by most bacterial beta-lactamases particularly those produced by gram-negative organisms. Ceftriaxone (Cefone) has relatively long plasma elimination half-life of approximately 8 hours, which offers single or once-daily dose of the drug.