COMPOSITION
Clamoxyl Tablet: Each film coated tablet contains Amoxicillin Trihydrate BP equivalent to Amoxicillin 500 mg and Potassium Clavulanate BP equivalent to Clavulanic Acid 125 mg.
PHARMACOLOGY
Pharmacodynamic properties: Clamoxyl is an antibacterial combination consisting of the
antibiotic Amoxicillin and the Beta lactamase inhibitor Clavulanic Acid. Amoxicillin has a
broad spectrum of bactericidal activity against many Gram-positive & Gram-negative
microorganisms but it is susceptible to degradation by Betalactamases and therefore the
spectrum of activity does not include microorganisms, which produce these enzymes.
Clavulanic acid possesses the ability to inactivate a wide range of beta-lactamase
enzymes commonly found in microorganisms resistant to penicillins and cephalosporins.
Thus Clavulanic acid in Clamoxyl protects Amoxicillin from degradation by Beta
lactamase enzymes and effectively extends the antibiotic spectrum to embrace a wide
range of microorganisms.
Pharmacokinetic properties:
The pharmacokinetics of the two components of Clamoxyl
is closely matched. Peak serum levels of both occur about one hour after oral
administration. Both clavulanate and Amoxicillin have low levels of serum binding; about
70% remains free in the serum.
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